Increased knowledge of the gene–disease associations contributing to common cancer development raises the prospect of population stratification by genotype and other risk factors. Individual risk assessments could be used to target interventions such as screening, treatment and health education. Genotyping neonates, infants or young children as part of a systematic programme would improve coverage and uptake, and facilitate a screening package that maximises potential benefits and minimises harms including overdiagnosis. This paper explores the potential justifications and risks of genotyping children (...) for genetic variants associated with common cancer development within a personalised screening programme. It identifies the ethical and legal principles that might guide population genotyping where the predictive value of the testing is modest and associated risks might arise in the future, and considers the standards required by population screening programme validity measures . These are distinguished from the normative principles underpinning predictive genetic testing of children for adult-onset diseases—namely, to make best-interests judgements and to preserve autonomy. While the case for population-based genotyping of neonates or young children has not yet been made, the justifications for this approach are likely to become increasingly compelling. A modified evaluative and normative framework should be developed, capturing elements from individualistic and population-based approaches. This should emphasise proper communication and genuine parental consent or informed choice, while recognising the challenges associated with making unsolicited approaches to an asymptomatic group. Such a framework would be strengthened by complementary empirical research. (shrink)

The Reputation of Justice Oliver Wendell Holmes, Jr., one of the chief architects of twentieth century American law, has gone through a number of phases, changing from being altogether praiseworthy in the last years of his life and the first years after his death in 1935 to that of more sober evaluations. Writing at mid-century Henry Steele Commager offered the judgment that Holmes had had about him “much of the Olympian [and] something of the Mephistophelean.” The most useful account of (...) how the winds of change swept along Holmes' reputation is an article by G. Edward White, “The Rise and Fall of Justice Holmes,” which appeared in the University of Chicago Law Review in 1971. White examined the myth of Justice Holmes as it obtained from 1932 to 1940 and then proceeded to describe the demythologizing of Holmes from 1941 through 1949. (shrink)

The poetic art of Edwin Arlington Robinson mirrored remarkably the sources of the American mind of his generation and the growth nurtured by these sources.

From 2012 to 2015 I was the first Eugene H. Fram Chair in Applied Critical Thinking at Rochester Institute of Technology, in Rochester, NY. To the best of my knowledge it is the only such endowed position devoted solely to this at a major North American university. It was made possible by a generous 3 million dollar gift from an anonymous alumnus who wished to honor a retired faculty member who had taught for 51 years. The honoree was revered for (...) his devotion to Bloom’s taxonomy and his academic rigor, which infused case studies and the Socratic method. A primary motivation for the chair was a belief that an alarming number of college graduates lack the necessary critical thinking skills in order to advance successfully in their careers. My responsibilities included collaborative leadership, advocacy and oversight for critical thinking across the entire campus. It provided a unique opportunity to reflect on the current state of critical thinking instruction–very broadly construed, as well as to examine its specific role at RIT, an institution with its own unique history, mission, and character. (shrink)

People are beginning to think of Manilius as the spoilt child of Latin Scholarship. In England alone there have appeared editions of, or works upon, Manilius, in the seventeenth century by Sherburne and Creech, in the eighteenth by Bentley and Burton, in the nineteenth by Ellis and Postgate, and in the current century by Housman. The contribution of France also has been considerable in quality, if not in quantity—Scaliger, Huetius, Pingré: though to-day there is no eminent French student of (...) Manilius. Of the German editors we might say what Aristophanes says of the Athenian generals. (shrink)

This paper argues that Quaker business ethics can be understood as a MacIntyrean tradition. To do so, it draws on three key MacIntyrean concepts: community, compartmentalisation, and the critique of management. The emphasis in Quaker business ethics on finding unity, as well as the emphasis that Quaker businesses have placed on serving their local areas, accords with MacIntyre’s claim that small-scale community is essential to human flourishing. The emphasis on integrity in Quaker business ethics means practitioners are well-placed to resist (...) the compartmentalising pressures of contemporary work. Quaker business ethics is also highly critical of the manipulative forms of management that MacIntyre regards as dominant. As such, Quaker business ethics provides evidence that more morally ameliorative forms of running business organisations is possible, even if they remain difficult to achieve. (shrink)

This is one of the most justly celebrated texts of the Chinese tradition - impressive for both its bold philosophical imagination and its striking literary style. Accepting the challenge of translating this captivating classic in its entirety, Burton Watson has expertly rendered into English both the profound thought and the literary brilliance of the text.

This is Daoist philosophy’s central tenet, espoused by the person—or group of people—known as Zhuangzi (369?-286? B.C.E.) in a text by the same name.

Mozi (fifth century B.C.) was an important political and social thinker and formidable rival of the Confucianists. He advocated universal love -- his most important doctrine according to which all humankind should be loved and treated as one's kinfolk -- honoring and making use of worthy men in government, and identifying with one's superior as a means of establishing uniform moral standards. He also believed in the will of Heaven and in ghosts. He firmly opposed offensive warfare, extravagance -- including (...) indulgence in music and allied pleasures -- elaborate funerals and mourning, fatalistic beliefs, and Confucianism. (shrink)

Compiling in one volume the basic writings of these three seminal thinkers of ancient China, each from a different philosophical school, this book reveals the richness and diversity of the ancient Chinese intellectual world.

Only by inhabiting Dao and dwelling in its unity can humankind achieve true happiness and freedom, in both life and death. This is Daoist philosophy's central tenet, espoused by the person--or group of people--known as Zhuangzi in a text by the same name. To be free, individuals must discard rigid distinctions between right and wrong, and follow a course of action not motivated by gain or striving. When one ceases to judge events as good or bad, man-made suffering disappears, and (...) natural suffering is embraced as part of life. Zhuangzi elucidates this mystical philosophy through humor, parable, and anecdote, using non sequitur and even nonsense to illuminate truths beyond the boundaries of ordinary logic. Boldly imaginative and inventively written, the _Zhuangzi_ floats free of its historical period and society, addressing the spiritual nourishment of all people across time. One of the most justly celebrated texts of the Chinese tradition, the _Zhuangzi_ is read by thousands of English-language scholars each year, yet, until now, only in the Wade-Giles romanization. Burton Watson's conversion to pinyin in this book brings the text in line with how Chinese scholars, and an increasing number of other scholars, read it. (shrink)

Xunzi asserted that the original nature of man is evil, differing on this point from Mencius, his famous predecessor in the Confucian school. In the most complete, well-ordered philosophical system of his day, Xunzi advocated the counteraction of man's evil through self-improvement, the pursuit of learning, the avoidance of obsession, and observance of ritual in life. Readers familiar with Xunzi's work will find that Burton Watson's lucid translation breathes new life into this classic. Those new to Xunzi will find (...) his ideas on government, language, and order and safety in society surprisingly close to concerns of our own age. (shrink)

Compiled by disciples of Confucius in the centuries following his death in 479 B.C.E., _The Analects of Confucius_ is a collection of aphorisms and historical anecdotes embodying the basic values of the Confucian tradition: learning, morality, ritual decorum, and filial piety. Reflecting the model eras of Chinese antiquity, the Analects offers valuable insights into successful governance and the ideal organization of society. Filled with humor and sarcasm, it reads like a casual conversation between teacher and student, emphasizing the role of (...) the individual in the attainment of knowledge and the value of using historical events and people to illuminate moral and political concepts. Confucius's teachings focus on cultural and peaceful pursuits and the characteristics of benevolent and culturally distinguished government. He also discusses ancestor worship and other rites performed for the spirits of the dead. The single most influential philosophical work in all of Chinese history, _The Analects of Confucius_ has shaped the thought and customs of China and neighboring countries for centuries. Burton Watson's concise translation uses the pinyin romanization system and keeps explanatory notes to a minimum, yet his intimate knowledge of the Confucian tradition and precise attention to linguistic detail capture the original text's elegance, cogency, and wit. (shrink)

The thoughts and writings of this important fifth century B.C. political and social thinker -- and formidable rival of the Confucianists -- are presented here in English translation.

The basic writings of Chuang Tzu have been savored by Chinese readers for over two thousand years. And Burton Watson's lucid and beautiful translation has been loved by generations of readers. Chuang Tzu was a leading philosopher representing the Taoist strain in Chinese thought. Using parable and anecdote, allegory and paradox, he set forth, in the book that bears his name, the early ideas of what was to become the Taoist school. Central to these is the belief that only (...) by understanding Tao and dwelling in its unity can man achieve true happiness and freedom, in both life and death. _Chuang Tzu: Basic Writings_ includes the seven "inner chapters," which form the heart of the book, three of the "outer chapters," and one of the "miscellaneous chapters." Watson also provides an introduction, placing the philosopher in relation to Chinese history and thought. Witty and imaginative, enriched by brilliant imagery, and making sportive use of both mythological and historical personages, this timeless classic is sure to appeal to anyone interested in Chinese religion and culture. (shrink)

Representative of the Fachia, or Legalist, school of philosophy, the writings of Han Fei Tzu confront the issues of preserving and strengthening the state. His lessons remain timely as scholars continue to examine the nature and use of power. Burton Watson provides a new preface and a helpful introduction.

This study examines the use of a video news release in a specific story. Press coverage and editorial criticism in the case showed that journalists do not articulate sufficiently how the news owners' sway, through institutional controls, can lead to a hegemony of expedient action in the newsroom. Critical self-reflection by news workers will better enable journalists to ethically deliberate news choices that balance their responsibilities to owners, peers, and the public.

Compiled by disciples of Confucius in the centuries following his death in 479 B.C.E., _The Analects of Confucius_ is a collection of aphorisms and historical anecdotes embodying the basic values of the Confucian tradition: learning, morality, ritual decorum, and filial piety. Reflecting the model eras of Chinese antiquity, the Analects offers valuable insights into successful governance and the ideal organization of society. Filled with humor and sarcasm, it reads like a casual conversation between teacher and student, emphasizing the role of (...) the individual in the attainment of knowledge and the value of using historical events and people to illuminate moral and political concepts. Confucius's teachings focus on cultural and peaceful pursuits and the characteristics of benevolent and culturally distinguished government. He also discusses ancestor worship and other rites performed for the spirits of the dead. The single most influential philosophical work in all of Chinese history, _The Analects of Confucius_ has shaped the thought and customs of China and neighboring countries for centuries. Burton Watson's concise translation uses the pinyin romanization system and keeps explanatory notes to a minimum, yet his intimate knowledge of the Confucian tradition and precise attention to linguistic detail capture the original text's elegance, cogency, and wit. (shrink)

A philosophical analysis is offered of the relationship between knowledge and liberation in Buddhism. Buddhists often consider the knowledge of impermanence as a key to liberation from craving, attachment, and hence suffering. However, it can be objected that one may know that things are impermanent and yet still be subject to craving and attachment. In the face of this objection, critical consideration is given to five ways in which one might preserve the claim that a knowledge of things as they (...) actually are results in liberation from craving and attachment. Many Buddhists might in fact reject the thesis that knowledge alone, no matter how it is characterized, is a sufficient condition for liberation. (shrink)